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Interleukin-15 and the regulation of lymphoid homeostasis
James Lodolce1, Patrick Burkett, Rima Koka
1Department of Medicine and the Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Avenue MC 6084, Chicago, IL 60637, USA.
Molecular Immunology
|November 15, 2002
Abstract:
Interleukin-15 (IL-15) is a cytokine that plays unique roles in both innate and adaptive immune cell homeostasis. While early studies suggested that IL-15 resembled IL-2, more recent work suggests that IL-15 may play multiple unique roles in immune homeostasis befitting its pleiotropic expression pattern. This review will focus on recent studies that highlight some of these functions.