Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum diiodotyrosine.

J C Nelson, R M Weiss, F J Palmer

    The Journal of Clinical Endocrinology and Metabolism
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Residual Activity of Pyriproxyfen Against Mosquitoes in Catch Basins in Northwestern Riverside County, Southern California.

    Journal of the American Mosquito Control Association·2021
    Same author

    The Treatment of Cholera by Cresol.

    The Indian medical gazette·2017
    Same author

    The Acid and Sanitol Treatment of the Intestinal Fluxes.

    The Indian medical gazette·2017
    Same author

    Hot Weather Ear-A Clinical Entity.

    The Indian medical gazette·2017
    Same author

    The Treatment of Cholera by Cresol and Acid.

    The Indian medical gazette·2017
    Same author

    The Causal Organism of Cholera.

    The Indian medical gazette·2017
    Same journal

    Children's neurodevelopment at school age after hysterosalpingography with iodinated contrast: a cohort study.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Bone phenotype of patients with genetic forms of lipodystrophy: a systematic review of literature.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    The Extra X Chromosome and Autoimmune Susceptibility in Klinefelter Syndrome.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Pathophysiology-Based Classification of Male Infertility: Evidence from an 800-patient Prospective Cohort.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Parathyroid Carcinoma: From Molecular Pathogenesis to Multidisciplinary Management.

    The Journal of clinical endocrinology and metabolism·2026
    Same journal

    Genetic and Clinical Factors Associated With Metformin Plasma Concentrations Following an Acute Metformin Challenge.

    The Journal of clinical endocrinology and metabolism·2026
    See all related articles

    Serum diiodotyrosine (DIT) levels vary with age and thyroid conditions. This study measured DIT in healthy individuals, thyroid patients, and animals, revealing significant species differences and age-related declines.

    Area of Science:

    • Endocrinology
    • Thyroid Research
    • Biochemistry

    Background:

    • Serum diiodotyrosine (DIT) is a key intermediate in thyroid hormone synthesis.
    • Understanding DIT levels is crucial for assessing thyroid function and related disorders.

    Purpose of the Study:

    • To quantify serum DIT levels in healthy adults, patients with thyroid disease, and various animal species.
    • To investigate the influence of age, sex, and thyroid status on serum DIT concentrations.

    Main Methods:

    • Radioimmunoassay (RIA) was employed to measure serum DIT concentrations.
    • Data were collected from 92 healthy adults, patients with thyroid conditions, and multiple laboratory animal models.

    Main Results:

    • Healthy adults had a mean serum DIT level of 101 ng/100 ml, with levels decreasing with age but showing no sex difference.

    Related Experiment Videos

  • Athyrotic subjects exhibited reduced DIT levels (mean 52 ng/100 ml), while hyperthyroid subjects showed non-significantly higher levels (mean 149 ng/100 ml).
  • Significant interspecies variations in serum DIT were observed, ranging from 17 ng/100 ml in mice to 428 ng/100 ml in dogs.

    • Conclusions:

    • Serum DIT levels are influenced by thyroid status and aging.
    • Significant species-specific differences in DIT levels highlight the importance of species-specific reference ranges.
    • Radioimmunoassay provides a reliable method for quantifying serum DIT in diverse physiological and pathological states.