Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain interleukin-1 is involved in spatial memory and passive avoidance conditioning.

R Yirmiya1, G Winocur, I Goshen

  • 1Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel. razyirmiya@huji.ac.il

Neurobiology of Learning and Memory
|November 15, 2002
PubMed
Summary

Interleukin-1 (IL-1) signaling in the hippocampus is crucial for learning and memory. Blocking IL-1 receptors impairs memory, while IL-1beta enhances it, suggesting a key role in cognitive processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dramatic changes to well-known places go unnoticed.

Neuropsychologia·2024
Same author

Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Ill-defined problem solving in amnestic mild cognitive impairment: linking episodic memory to effective solution generation.

Neuropsychologia·2015
Same author

Effects of cue manipulation on performance by old and young rats in a test of non-matching-to-sample.

Behavioural processes·2014
Same author

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis.

Molecular psychiatry·2013
Same author

What Is Special about Face Recognition? Nineteen Experiments on a Person with Visual Object Agnosia and Dyslexia but Normal Face Recognition.

Journal of cognitive neuroscience·2013

Area of Science:

  • Neuroscience
  • Immunology
  • Behavioral Science

Background:

  • The inflammatory cytokine interleukin-1 (IL-1) is known to mediate illness responses.
  • Its specific role in normal learning and memory processes remains unclear.

Purpose of the Study:

  • To investigate the function of IL-1 signaling in hippocampal-dependent learning and memory.
  • To determine the effects of IL-1beta and IL-1 receptor antagonist (IL-1ra) on memory consolidation.

Main Methods:

  • Long-Evans rats received intracerebroventricular infusions of IL-1beta, IL-1ra, or saline post-learning.
  • Memory was assessed using the Morris water maze (spatial and non-spatial versions) and a passive avoidance task.

Main Results:

Related Experiment Videos

  • IL-1ra administration impaired memory in the hippocampus-dependent spatial Morris water maze and passive avoidance tasks.
  • IL-1beta administration improved memory in the passive avoidance task but had no effect in the Morris water maze.
  • Neither treatment affected the hippocampus-independent non-spatial Morris water maze.

    • Conclusions:

    • IL-1 signaling within the hippocampus plays a critical role in learning and memory processes.
    • The balance of IL-1 activity is important for normal memory function.