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Published on: January 18, 2011
Structural and functional diversities of the Aplysia Mytilus inhibitory peptide-related peptides
Kosei Sasaki1, Yoriko Shimizu, Genbu Abe
1Graduate School of Science, Department of Biological Science, Hiroshima University, Kagamiyama 1-3-1, Japan.
Abstract:
Aplysia Mytilus inhibitory peptide-related peptides (AMRPs) are multiple hexapeptides coded on a single precursor. By comparing the AMRP precursors of two species of Aplysia (Aplysia californica and Aplysia kurodai), we found that there are substantial numbers of species-specific AMRPs. We next compared the function of AMRPs on the anterior aorta between A. kurodai and Aplysia juliana. In A. juliana, AMRPs inhibited the contractile activity of the aorta (EC(50)=10(-9) to 10(-8)M), whereas the peptides had no obvious action in A. kurodai up to 10(-7)M. These results indicate that AMRPs are both structurally and functionally diverse neuropeptides even among closely related species.
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