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Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland
Published on: November 16, 2017
Current approaches for deciphering the molecular basis of combined anterior pituitary hormone deficiency in humans
1Institut National de la Santé et de la Recherche Médicale (Unité 468), Hôpital Henri-Mondor, Créteil 94010, France. serge.amselem@im3.inserm.fr
Abstract:
This review focuses on the general strategies currently used to decipher the molecular bases of combined pituitary hormone deficiency (CPHD) of genetic origin. By summarizing illustrative approaches that turned out to be successful for identifying an increasing number of genes involved in CPHD in the human, this article consider predictable obstacles specific to the investigation of these rare and heterogeneous conditions, while underlining the previously unsuspected roles of several of these genes during the development of extrapituitary structures.
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