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Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
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Published on: November 18, 2013

Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain

Eva Chmielnicki1, Steven A Goldman

  • 1Department of Neurology and Neuroscience, Cornell University Medical College, 1300 York Ave., Room E607, New York, NY 10021, USA.

Progress in Brain Research
|November 16, 2002
PubMed
Abstract

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...