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Updated: Jan 20, 2026
Microscopic Imaging of Neurons in a Mouse Brain Section Using Golgi-Cox Metallic Staining
Published on: April 28, 2025
Distinct functions of COX-1 and COX-2
1Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan. morita.cell@dent.tmd.ac.jp
Abstract:
The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-1 (COX-1) and COX-2. The properties of COX-1 are different from those of COX-2. It was originally thought that the function of COX-1 was involved in physiological phenomena, whereas that of COX-2 was involved in various pathologies. However, studies with COX-2 knockout mouse suggest that COX-2 also plays important roles in development and homeostasis. This chapter focuses on the distinct functions of COX-1 and COX-2.
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