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Cyclopentenone prostaglandin receptors
Manabu Negishi1, Hironori Katoh
1Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Japan. mnegishi@pharm.kyoto-u.ac.jp
Prostaglandins & Other Lipid Mediators
|November 16, 2002
Summary
Cyclopentenone prostaglandins (PGs) regulate cell functions by influencing gene expression. Specific PGs, like 15d-delta(12,14)-PDJ2, activate nuclear receptors, promoting cell differentiation and stress responses.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Cyclopentenone prostaglandins (PGs) are signaling molecules involved in cellular processes.
- These PGs are actively transported into cells, influencing gene expression.
Purpose of the Study:
- To investigate the mechanisms by which cyclopentenone PGs regulate gene expression.
- To identify specific cyclopentenone PGs and their cellular targets.
Main Methods:
- Analysis of gene expression patterns.
- Identification of nuclear receptor binding.
- Study of stress gene induction.
Main Results:
- Cyclopentenone PGs, including 15d-delta(12,14)-PDJ2, delta12-PGJ2, and PGA2, promote gene expression.
- 15d-delta(12,14)-PDJ2 binds to peroxisome proliferator-activated receptor gamma (PPARγ), inducing adipogenesis.
- Cyclopentenone PGs activate stress genes like heat shock proteins (HSPs), BiP, and PDI via specific response elements.
Conclusions:
- Cyclopentenone PGs are key regulators of cell growth, differentiation, and stress responses.
- Their effects are mediated through the modulation of diverse gene expression pathways.