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Related Experiment Videos

Epigenomics: genome-wide study of methylation phenomena.

K L Novik1, I Nimmrich, B Genc

  • 1Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. kln@sanger.ac.uk

Current Issues in Molecular Biology
|November 16, 2002
PubMed
Summary

Epigenetics, the study of gene expression without altering DNA sequence, reveals genome plasticity. The emerging field of epigenomics, including the Human Epigenome Project (HEP), enables genome-wide epigenetic analysis.

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Area of Science:

  • Genomics and Molecular Biology
  • Epigenetics and Epigenomics

Background:

  • Epigenetics explains differential gene expression across human cells with identical genomes.
  • Epigenetic modifications, particularly DNA methylation, influence gene regulation, chromatin structure, and disease.
  • The Human Genome Project (HGP) paved the way for genome-wide epigenetic studies.

Purpose of the Study:

  • To review the current and future potential of epigenomics.
  • To introduce the pilot study for the Human Epigenome Project (HEP).

Main Methods:

  • Genome-wide analysis of epigenetic phenomena.
  • Focus on differential methylation patterns (epigenomes).

Main Results:

  • Epigenomics allows for comprehensive study of epigenetic modifications.

Related Experiment Videos

  • Pilot studies are underway for the Human Epigenome Project.

    • Conclusions:

    • Epigenomics is a crucial emerging field for understanding genome function and plasticity.
    • The HEP aims to map human epigenomes comprehensively.