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Related Experiment Videos

Intranasal corticosteroids for allergic rhinitis.

Amanda J Trangsrud1, Amy L Whitaker, Ralph E Small

  • 1Department of Pharmacy Practice, College of Pharmacy, Midwestern University, Glendale, Illinois, USA.

Pharmacotherapy
|November 16, 2002
PubMed
Summary

Intranasal corticosteroids are safe and effective for allergic rhinitis, relieving symptoms like congestion and sneezing. These topical treatments offer localized relief with minimal systemic side effects for seasonal and perennial allergies.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology

Background:

  • Allergic rhinitis significantly impacts quality of life.
  • Intranasal corticosteroids (INCS) are a primary treatment modality.

Purpose of the Study:

  • To review the efficacy and safety of available INCS for allergic rhinitis.
  • To highlight the mechanism of action and adverse effect profiles.

Main Methods:

  • Review of existing literature on INCS for allergic rhinitis.
  • Analysis of clinical trial data regarding symptom control and safety.

Main Results:

  • All listed INCS (beclomethasone dipropionate, budesonide, flunisolide, fluticasone propionate, mometasone furoate, triamcinolone acetonide) are effective for seasonal and perennial allergic rhinitis.

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  • INCS provide significant relief from nasal congestion, itching, rhinorrhea, and sneezing, with notable prevention of late-phase allergic responses.
  • Adverse effects are generally mild and localized to the nasal mucosa, including dryness, burning, sneezing, headache, and epistaxis in 5-10% of patients.

    • Conclusions:

    • Intranasal corticosteroids are a well-established, safe, and effective first-line therapy for allergic rhinitis.
    • Topical application ensures adequate drug concentration in the nasal mucosa, maximizing efficacy and minimizing systemic risks.
    • Differences between agents primarily relate to potency, formulation, and delivery devices, allowing for patient-specific treatment selection.