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Coregulators of estrogen receptor action
Gilles B Tremblay1, Vincent Giguère
1Drug Discovery Unit, SignalGene Inc., Montréal, Canada. gillest@signalgene.com
Critical Reviews in Eukaryotic Gene Expression
|November 16, 2002
Summary
Estrogen receptors, a key part of the nuclear receptor family, interact with coregulator proteins to regulate gene expression. This review explores these crucial interactions in transmitting estrogenic signals.
Area of Science:
- Molecular Biology
- Endocrinology
- Genetics
Background:
- Estrogen receptors (ERs) belong to the nuclear receptor superfamily, involved in cellular signaling.
- Nuclear receptors, including ERs, interact with coregulator proteins to modulate gene expression.
- These interactions are vital for transmitting signals from lipophilic molecules in target tissues.
Purpose of the Study:
- To provide an overview of regulatory factors interacting with estrogen receptors.
- To explain the role of these factors in the estrogenic signaling pathway.
- To highlight the complexity of transcriptional regulation by nuclear receptors.
Main Methods:
- Literature review of studies on estrogen receptors and coregulators.
- Analysis of molecular mechanisms involved in nuclear receptor-mediated gene regulation.
- Synthesis of information on protein-protein interactions and chromatin remodeling.
Main Results:
- Identified various coregulator proteins that associate with estrogen receptors.
- Described the enzymatic and structural activities of these coregulators.
- Highlighted the role of coregulators in modulating chromatin structure for gene expression control.
Conclusions:
- Coregulator proteins are essential for estrogen receptor function.
- The interaction network between ERs and coregulators is complex and critical for signal transduction.
- Understanding these interactions provides insight into estrogenic signaling and gene regulation.