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Extent of resection for hepatocellular carcinoma 2 cm or less in greatest diameter
Masakazu Yamamoto1, Ken Takasaki, Takehito Otsubo
1Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan. m-yama@jg7.so-net.ne.jp
Background:
The effectiveness of liver segmentectomy or larger resection in patients with hepatocellular carcinoma (HCC) 2 cm or less in greatest diameter has not been clarified.
Methods:
From 1985 to 1994, 125 patients with solitary HCC 2 cm or less in greatest diameter underwent curative hepatectomy (liver segmentectomy or larger resection, 94; subsegmentectomy, 31). The relationship between clinicopathological findings and surgical outcomes were examined.
Results:
The 5- and 10-year survival rates were 68% and 47%, respectively. Univariate and multivariate analysis showed the Child-Pugh class to be a significant prognostic factor. However, liver segmentectomy or larger resection did not have any significant effect on long-term survival.
Conclusions:
Our data suggest that no further improvement of the survival rate can be achieved by liver segmentectomy or larger resection, compared with subsegmentectomy in patients with solitary HCC 2 cm or less in greatest diameter.