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[Effects of Azone of different concentrations on percutaneous absorption of baicalin in vitro]
Zhi-Ping L1, Qiang Liu, Xin-Wei Lu
1Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China.
Objective:
To study the effects of azone on the percutaneous absorption of baicalin in vitro.
Methods:
Using the skin of nude mice as the cutaneous barrier, the rate constants of percutaneous absorption of baicalin at various concentrations of Azone were determined.
Results:
The rate constants were 76.07, 89.23, 167.36, 238.61, 200.45 and 171.49 microgram cm-2.h-1 respectively corresponding to the concentrations of Azone at 0, 2%, 4%, 6%, 8%, and 10%.
Conclusion:
C Azone can enhance percutaneous absorption of baicalin, exerting its maximum effect at the concentration of 6%.
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