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O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
Published on: October 6, 2022
Dance band on the Titanic: biomechanical signaling in cardiac hypertrophy
Mark A Sussman1, Andrew McCulloch, Thomas K Borg
1Children's Hospital and Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, Ohio, USA.
Abstract:
Biomechanical signaling is a complex interaction of both intracellular and extracellular components. Both passive and active components are involved in the extracellular environment to signal through specific receptors to multiple signaling pathways. This review provides an overview of extracellular matrix, specific receptors, and signaling pathways for biomechanical stimulation in cardiac hypertrophy.
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