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Related Experiment Videos

Peak exercise stroke volume: associations with cardiac structure and diastolic function.

Linda R Peterson1, Morton R Rinder, Kenneth B Schechtman

  • 1Claude D. Pepper Older Americans Independence Center, Washington University School of Medicine, St. Louis, Missouri 63110, USA. lpeterso@im.wustl.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 16, 2002
PubMed
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Maintaining good left ventricular (LV) filling is linked to better peak exercise stroke volume in older adults. Arterial stiffness markers predict cardiac remodeling but not exercise capacity.

Area of Science:

  • Cardiovascular Physiology
  • Gerontology
  • Exercise Science

Background:

  • Aging leads to decreased aerobic exercise capacity, partly due to reduced peak exercise stroke volume.
  • Understanding age-related cardiovascular changes is crucial for maintaining physical function in the elderly.

Purpose of the Study:

  • To identify cardiovascular adaptations influencing peak exercise stroke volume in the elderly.
  • To determine factors predicting left ventricular (LV) remodeling in aging individuals.

Main Methods:

  • Cross-sectional study of 52 sedentary elderly subjects.
  • Assessed cardiac adaptations (LV filling via E/A ratio) and vascular adaptations (augmentation index - AI).
  • Correlated these with peak exercise stroke volume/lean body mass (LBM) and LV remodeling metrics.

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Main Results:

  • LV filling (E/A ratio) was inversely correlated with and predicted peak exercise stroke volume/LBM.
  • Augmentation index (AI) predicted LV remodeling (LV mass/LBM) but not peak exercise stroke volume/LBM.
  • LV remodeling and AI had less influence on peak exercise stroke volume/LBM compared to LV filling.

Conclusions:

  • Maintenance of LV filling (E/A <1) is associated with higher peak exercise stroke volume/LBM in the elderly, enhancing exercise capacity.
  • LV remodeling and arterial stiffness (AI) are less critical for peak exercise stroke volume but AI is a key predictor of LV remodeling.