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Neurotrophins and the control of axonal outgrowth
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. klt@fmi.ch
Panminerva Medica
|November 16, 2002
Abstract:
The neurotrophins NGF, BDNF, NT-3, and NT-4/5 are well known for their neuron survival-promoting functions. This review focuses upon a less-investigated function of this gene family, namely that of controlling the growth of axons in vivo. Recent evidence is discussed that reveals a definitive requirement for neurotrophin signaling in the elongation of peripheral nerves during embryonic development.