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Updated: Aug 9, 2026
09:47
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
[Sclerotic dentin: aetio-pathogenetic hypotheses]
L Giachetti1, E Ercolani, C Bambi
1Cattedra di Materiali Dentari, Università degli Studi di Firenze, Florence, Italy. l.giachetti@odonto.unifi.it
Minerva Stomatologica
|November 16, 2002
Summary
Dentinal sclerosis involves changes in dentin tubules, potentially causing obstruction. This condition is multifactorial, resulting from increased mineral content and calcium salt precipitation within dentinal tubules.
Area of Science:
- Dental Science
- Mineralogy
- Histology
Context:
- Dentinal sclerosis is a complex dental condition affecting dentin structure.
- Understanding its formation is crucial for diagnosing and managing dentin-related issues.
Purpose:
- To review current knowledge on dentinal sclerosis.
- To analyze the structural changes observed in sclerotic dentin using SEM and TEM.
- To discuss hypotheses regarding the genesis of dentinal sclerosis.
Summary:
- SEM and TEM reveal altered dentinal tubules with lumen obstruction due to neo-apposition of peri-tubular dentin and intra-tubular deposition of Whitelockite crystals.
- Sclerotic casts form within tubules, sometimes with central cavities, often surrounded by fissures.
- Increased mineral content is observed, but whether it's quantitative or due to hyper-mineralization is debated.
- Existing hypotheses on genesis include passive dissolution-precipitation and active odontoblastic/pulp involvement.
- Dentinal sclerosis is considered a multifactorial event involving increased peri-tubular dentin thickness and intra-tubular calcium salt precipitation.
Impact:
- Provides a comprehensive overview of dentinal sclerosis.
- Highlights areas of ongoing debate and future research directions.
- Contributes to a better understanding of dentin's response to stimuli.
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