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Does coffee protect against hepatocellular carcinoma?

S Gallus1, M Bertuzzi, A Tavani

  • 1Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy. gallus@marionegri.it

British Journal of Cancer
|November 16, 2002
PubMed
Summary

Coffee consumption may reduce the risk of hepatocellular carcinoma (liver cancer). Drinking three or more cups daily was associated with a lower risk in a study of Italian and Greek adults.

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Epidemiology

Background:

  • Hepatocellular carcinoma (HCC) is a significant global health concern.
  • Lifestyle factors, including diet and beverage consumption, are investigated for their role in HCC development.

Purpose of the Study:

  • To investigate the association between coffee consumption and the risk of developing hepatocellular carcinoma (HCC).

Main Methods:

  • Two case-control studies were conducted in Italy and Greece.
  • Data included 834 HCC cases and 1912 control participants.
  • Multivariate analysis was used to assess the odds ratio for coffee consumption.

Main Results:

  • Coffee drinkers consuming three or more cups per day showed a reduced risk of HCC.

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  • The multivariate odds ratio for high coffee consumption was 0.7 compared to non-drinkers.

    • Conclusions:

    • Coffee consumption appears to be associated with a decreased risk of hepatocellular carcinoma.
    • Further research can explore the specific mechanisms underlying this protective effect.