Sarcoidosis and uveitis

Sarcoidosis is a disease initiated by one or more unknown antigens in predisposed hosts, and causes noncaseating granulomatous inflammation. Uveitis is common and may affect any part of the eye. Protean systemic manifestations occur but pulmonary and cutaneous involvement is most common. Diagnosis is important; any suspicious uveitis should be investigated by relevant hematologic, radiologic, and invasive tests. A high proportion of patients require systemic corticosteroid or immunosuppressive treatment for uveitis. A significant minority become visually disabled because of macular scarring, glaucoma, or chorioretinal ischemia.