Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current status of prophylactic mastectomy.

Karthik Ghosh1, Lynn C Hartmann

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Oncology (Williston Park, N.Y.)
|November 19, 2002
PubMed
Summary

For women at high risk of breast cancer, prophylactic mastectomy is a controversial option. This review evaluates its effectiveness, risks, and psychosocial impact compared to alternatives like surveillance and chemoprevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Term Survival in High-Grade Serous Ovarian Cancer Compared With the General US Population: A 30-Year Landmark Analysis.

JCO oncology advances·2026
Same author

Histologic correlates of background parenchymal uptake on molecular breast imaging.

Breast cancer research : BCR·2025
Same author

Primary Care Clinician Preferences and Perspectives on Multi-Cancer Detection Testing Across an Integrated Healthcare System.

Journal of personalized medicine·2025
Same author

Analysis of Biopsy Modalities and Timeline for the Workup of Undiagnosed Lesions: Mayo Clinic Experience.

Southern medical journal·2025
Same author

A randomized trial to evaluate the impact of breast density notification on anxiety, breast cancer worry, and perceived risk among Latinas at a federally qualified health center : Breast density notification and anxiety, breast cancer worry, and perceived risk among Latinas.

BMC women's health·2025
Same author

The Use of an Artificial Intelligence Platform OpenEvidence to Augment Clinical Decision-Making for Primary Care Physicians.

Journal of primary care & community health·2025

Area of Science:

  • Oncology
  • Surgical Oncology
  • Preventive Medicine

Background:

  • Management of high-risk women for breast cancer poses challenges.
  • Current options include surveillance, prophylactic surgery, and chemoprevention.
  • Prophylactic mastectomy is a controversial clinical choice.

Purpose of the Study:

  • To review the efficacy of prophylactic mastectomy in reducing breast cancer risk.
  • To examine the utilization, complications, and psychosocial effects of prophylactic mastectomy.
  • To inform decision-making for high-risk women.

Main Methods:

  • Literature review on prophylactic mastectomy in high-risk populations.
  • Analysis of efficacy, surgical outcomes, and patient-reported impacts.
  • Comparison with alternative risk-management strategies.

Main Results:

  • Prophylactic mastectomy can significantly reduce breast cancer incidence in high-risk women.
  • The procedure carries surgical risks and significant psychosocial considerations.
  • Decision-making requires thorough risk assessment and discussion of alternatives.

Conclusions:

  • Prophylactic mastectomy is an option for high-risk women, but requires careful consideration.
  • Informed consent must include benefits, risks, and alternatives like chemoprevention and surveillance.
  • Personalized risk assessment is crucial for guiding management decisions.

Related Experiment Videos