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Related Experiment Videos

Occasion setting and drug tolerance.

Barbara M C Ramos1, Shepard Siegel, José Lino O Bueno

  • 1McMaster University, Hamilton, Ontario, Canada.

Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society
|November 19, 2002
PubMed
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Drug cues act as both conditional stimuli and occasion setters, influencing drug tolerance. Understanding these dual roles is key to explaining tolerance and developing addiction treatments.

Area of Science:

  • Behavioral neuroscience
  • Psychopharmacology
  • Learning and memory

Background:

  • Drug-associated cues can elicit conditioned responses contributing to tolerance.
  • Previous research primarily viewed these cues as Pavlovian conditional stimuli (CSs).

Purpose of the Study:

  • To investigate if drug-paired cues can also function as occasion setters in addition to CSs.
  • To evaluate the contribution of occasion-setting stimuli to ethanol tolerance.

Main Methods:

  • Utilized feature-positive discrimination training in rats.
  • Assessed tolerance to the hypothermic effects of ethanol.

Main Results:

  • Drug-paired cues were established as both conditional stimuli and occasion setters.

Related Experiment Videos

  • Occasion-setting properties of cues significantly contributed to ethanol tolerance.

    • Conclusions:

    • A comprehensive analysis of drug tolerance requires considering both CS and occasion-setting properties of cues.
    • Findings impact the interpretation of tolerance extinction and cue-exposure therapies for addiction.