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Simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma: a potential pitfall in positron emission

Ralph Naumann1, Bettina Beuthien-Baumann, Rainer Fischer

  • 1Department of Internal Medicine I, University Hospital Carl Gustav Carus at the Dresden University of Technology, Dresden, Germany. naumann@mk1.med.tu-dresden.de

Clinical Lymphoma
|November 19, 2002
PubMed

Positron emission tomography (PET) with [18F]fluorodeoxyglucose [18F]FDG has evolved as a method of increasingly clinical importance in the management of patients with malignant lymphoma. However, inflammatory lesions also accumulate [18F]FDG and may cause difficulties with interpretation. This report deals with 2 patients with simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma, a rare but known coincidence of diseases. In the first case, Hodgkin's disease could not be differentiated from eosinophilic granuloma. Positron emission tomography showed increased [18F]FDG uptake both in lymphoma manifestations and in the granuloma. In the second case with proven Hodgkin's disease, post-treatment examination showed a positive PET lesion in the mediastinal residual mass, which was interpreted as viable lymphoma. However, histologic examination revealed that it was an eosinophilic granuloma.

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