Related Experiment Video
Updated: Sep 28, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
Published on: December 2, 2014
Arterial elastic properties and cardiovascular risk/event
K-S Cheng1, C R Baker, G Hamilton
1Cardiovascular Haemodynamic Unit, University Department of Surgery, Royal Free and University College Medical School, University College London and The Royal Free Hospital, London, UK.
Insights
Arterial elasticity is impaired in cardiovascular disease and its risk factors. Improving arterial elasticity through risk factor treatment can reduce cardiovascular events, with duplex estimation showing promise for clinical screening.
Area of Science:
- Cardiovascular Science
- Vascular Biology
- Biomedical Engineering
Background:
- Cardiovascular disease is a leading cause of death and illness globally.
- Impaired arterial elasticity is linked to cardiovascular disease and risk factors like smoking, hypertension, and diabetes.
- Improving arterial elasticity through risk factor management may reduce cardiovascular events.
Purpose of the Study:
- To explore the role of arterial elasticity in cardiovascular disease.
- To discuss challenges in measuring arterial elasticity.
- To evaluate duplex estimation as a method for assessing arterial properties.
Main Methods:
- Review of existing evidence on arterial elasticity and cardiovascular disease.
- Analysis of risk factors affecting arterial properties.
- Evaluation of duplex estimation as a non-invasive measurement technique.
Main Results:
- Arterial elasticity is compromised by cardiovascular disease and associated risk factors.
- Risk factor treatment can improve arterial elasticity and lower cardiovascular risk.
- Duplex estimation is a reliable, non-invasive method for assessing arterial properties.
Conclusions:
- Arterial elasticity assessment is crucial for understanding cardiovascular disease.
- Duplex estimation offers a viable tool for clinical screening of at-risk patients.
- Further integration of duplex estimation into clinical practice is warranted.
Abstract:
Cardiovascular disease is a major cause of morbidity and mortality in the western world. There is convincing evidence that the elastic properties, particularly of large arteries, are impaired in the presence of cardiovascular disease and risk factors such as cigarette smoking, hypertension, diabetes and ageing. Evidence is also emerging that treatment of these risk factors is associated with an improvement in the elastic properties, mirrored by a reduction in the cardiovascular risk and events. The main problems associated with arterial elasticity are the multiple definitions and methods of measurement and the problem of obtaining reliable nearby blood pressure measurement. Nevertheless, duplex estimation appears to be a non-invasive, accurate and reliable method of defining these properties. This method is broadly used as a research tool, but there is a good case for its use in clinical practice, particularly in the screening of patients at risk of cardiovascular events.
Related Concept Videos
Arteries and Arterioles
Pulse
The pulse serves as a clinical indicator...
Vascular Resistance
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Coronary Artery Disease I: Introduction
