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Renal injury from valproic acid: case report and literature review
Emad L Zaki1, James E Springate
1Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo and The Children's Hospital, Buffalo, New York 14222, USA.
Pediatric Neurology
|November 19, 2002
Abstract:
A child with developmental delay and epilepsy developed glucosuria approximately 16 months after starting valproic acid therapy. Laboratory evaluation revealed global defects in proximal tubule function consistent with the De Toni-Debré-Fanconi syndrome. Discontinuation of valproate led to complete recovery 5 months later. Review of previously reported cases indicates that this complication is unique to children and reversible when the medication is discontinued.