Jove
Visualize
Contact Us

Related Experiment Videos

Screening for bone metastases. Are only scans necessary?

I R McDougall, J P Kriss

    JAMA
    |January 6, 1975
    PubMed
    Summary

    Technetium 99m-labeled diphosphonate skeletal scintigraphy is more sensitive than roentgenograms for detecting cancer metastases. Scans identified more malignant lesions, significantly reducing false-negative rates in cancer staging.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    2-Deoxy-2-[F-18]fluoro-D-glucose positron emission tomography/computed tomography in the management of melanoma.

    Molecular imaging and biology·2006
    Same author

    Merkel cell carcinoma: Is there a role for 2-deoxy-2-[f-18]fluoro-D-glucose-positron emission tomography/computed tomography?

    Molecular imaging and biology·2006
    Same author

    Long-term results of irradiation for patients with progressive Graves' ophthalmopathy.

    International journal of radiation oncology, biology, physics·2001
    Same author

    Iodine and thyroid cancer risk among women in a multiethnic population: the Bay Area Thyroid Cancer Study.

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2001
    Same author

    Thyroid carcinoma after successful treatment of osteosarcoma: a report of three patients.

    Journal of pediatric hematology/oncology·2001
    Same author

    Positron emission tomography of the thyroid, with an emphasis on thyroid cancer.

    Nuclear medicine communications·2001
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Nuclear Medicine
    • Oncology
    • Radiology

    Background:

    • Skeletal metastases are a common complication of primary cancers.
    • Accurate detection of bone metastases is crucial for cancer staging and treatment planning.

    Purpose of the Study:

    • To compare the diagnostic accuracy of total skeletal scintigraphy using technetium 99m-labeled diphosphonate with roentgenographic examinations in patients with biopsy-proven primary cancer.
    • To determine the false-negative rates of both imaging modalities for detecting bone metastases.

    Main Methods:

    • Total skeletal scintigraphy with technetium 99m-labeled diphosphonate was performed on 200 patients with biopsy-proven primary cancer.
    • Results were compared with roentgenographic findings and biopsy data.
    • A regional analysis of scan and roentgenographic findings was conducted.

    Main Results:

    • Skeletal scintigraphy demonstrated abnormalities in 114 out of 200 patients.
    • Roentgenograms were normal in 57 patients, but 32 of these had malignant lesions detected by scintigraphy, resulting in a 17% false-negative rate for roentgenography.
    • Scans showed a 1.6% false-negative rate, with only three patients having abnormal roentgenograms but normal scans.
    • On a regional basis, scintigraphy detected 119 abnormalities not seen on roentgenograms, attributed to tumor, while roentgenograms showed only 17 unexplained false-negative findings compared to scans.

    Conclusions:

    • Total skeletal scintigraphy with technetium 99m-labeled diphosphonate is significantly more sensitive than roentgenography for detecting skeletal metastases in patients with primary cancer.
    • Skeletal scintigraphy offers a lower false-negative rate, improving the accuracy of cancer staging and management.

    Related Experiment Videos