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Colchicine for periodic peritonitis

H A Reimann

    JAMA
    |January 6, 1975
    PubMed

    Insights

    Colchicine effectively suppressed periodic peritonitis, also known as familial Mediterranean fever, in most patients after decades of failed treatments. This finding highlights colchicine

    Area of Science:

    • Internal Medicine
    • Rheumatology
    • Genetics

    Background:

    • Periodic peritonitis, including familial Mediterranean fever, has historically presented therapeutic challenges.
    • Previous treatment strategies over 25 years yielded limited success.

    Purpose of the Study:

    • To evaluate the efficacy of colchicine in managing periodic peritonitis.
    • To assess colchicine's role in patients with recurrent polyserositis.

    Main Methods:

    • A cohort of 14 patients with periodic peritonitis was treated with colchicine.
    • Continuous daily dosage of 0.65 mg was administered.
    • Intermittent therapy protocols are currently under investigation.

    Main Results:

    • Colchicine suppressed episodes in 12 out of 14 patients.
    • The drug demonstrated significant efficacy where prior trials failed.

    Conclusions:

    • Colchicine is a highly effective treatment for periodic peritonitis (familial Mediterranean fever).
    • Suppression of episodes by colchicine may serve as a diagnostic criterion.
    • Further research into intermittent dosing strategies is warranted.

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