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Pharmacologic influences on TMS effects.

Babak Boroojerdi1

  • 1Neurologiche Klinik, Universitätsklinikum, Aachen, Germany. Babak.Boroojerdi@post.rwth-aachen.de

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|November 19, 2002
PubMed
Summary

Transcranial magnetic stimulation (TMS) is a noninvasive tool to study human brain physiology, excitability, and plasticity. Combining TMS with pharmacology offers insights into the mechanisms of cortical plasticity and excitability.

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Area of Science:

  • Neuroscience
  • Neurophysiology

Background:

  • Transcranial magnetic stimulation (TMS) is increasingly utilized to investigate human cortical physiology.
  • This noninvasive technique allows for the assessment of cortical excitability and plasticity in various systems.

Purpose of the Study:

  • To review TMS paradigms for studying mechanisms of cortical plasticity.
  • To explore the use of pharmacologic interventions in conjunction with TMS to examine cortical excitability and plasticity.

Main Methods:

  • Review of existing literature on TMS applications in human motor and visual systems.
  • Discussion of TMS paradigms combined with pharmacologic agents.
  • Focus on studying plasticity and excitability in the intact human motor system.

Main Results:

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  • TMS provides a method to directly measure cortical excitability.
  • TMS can be employed to study both short- and long-term cortical plasticity.
  • Combining TMS with pharmacology is a viable approach to investigate underlying mechanisms.

Conclusions:

  • Pharmacologic interventions combined with TMS offer a powerful approach to elucidate mechanisms of human cortical plasticity and excitability.
  • This review details TMS paradigms suitable for such investigations in the motor system.