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Updated: Sep 28, 2026

Quantification of Cerebral Vascular Architecture using Two-photon Microscopy in a Mouse Model of HIV-induced Neuroinflammation
Published on: January 12, 2016
[Aids: is it a risk factor in cerebrovascular disease?]
P Casanova-Sotolongo1, P Casanova-Carrillo, C Casanova-Carrillo
1Policlinico Docente "Heroes del Moncada". Municipio de Salud Plaza, La Habana, Cuba. pcasanov@infomed.sld.cu
Insights
Cerebrovascular disease (CVD) is increasing in developing nations, often linked to HIV. Young patients with CVD should be tested for HIV, as it may be the primary cause.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Context:
- Cerebrovascular disease (CVD) is a growing global health concern.
- In developed nations, CVD is linked to aging populations and public health advancements.
- Developing countries are experiencing a rise in CVD, with factors beyond traditional risk factors implicated.
Purpose:
- To highlight the increasing incidence of cerebrovascular disease (CVD) in an underdeveloped country.
- To investigate the potential link between CVD and the high prevalence of human immunodeficiency virus (HIV).
Summary:
- A study of 155 patients admitted with CVD in Beira revealed that 56.7% were HIV-positive.
- CVD in individuals under 50 was generally not associated with other traditional risk factors.
- The findings suggest a significant role of HIV in CVD, particularly in younger populations.
Impact:
- Expect an increase in CVD morbidity and mortality in developing nations, narrowing the gap with developed countries.
- The occurrence of CVD in young individuals without other apparent causes necessitates HIV testing.
- This research underscores the importance of considering infectious diseases in the etiology of neurological conditions in resource-limited settings.
Introduction:
Cerebrovascular disease (CVD) has become an important health problem throughout the world. It is generally one the main causes of morbidity and mortality in the world, especially in developed countries. In these countries the frequency with which it appears is linked with the progress reached in the organisation of the public health system and the higher economic and social standards of their populations, which have given rise to prolonged life expectancy and a greater number of elderly people. In poor countries, however, in recent times there has also been an increase in the number of cases of this entity, although there is no correspondence with the arguments mentioned above concerning rich nations. The risk factors (RF) that are invoked when talking about its genesis must always be taken into account when dealing with its prevention. AIMS. To draw attention to the increase in the number of CVD in an under developed country, apparently due to the high frequency of the acquired immunodeficiency syndrome suffered by the population.
Patients And Methods:
A study was conducted involving all the patients admitted to the Hospital Central de Beira between 1 January 1988 and 30 June 1999 with a clinical picture compatible with a CVD. They had all been examined by a neurologist (always the same one) and had also been submitted to serological tests to detect the human immunodeficiency virus (HIV).
Results:
Of the 155 cases with CVD, 56.7% were HIV+. Below the age of 50, CVD is generally not associated with any other RF.
Conclusion:
These findings show that we must expect an increase in the morbidity and mortality from CVD in poor nations, which will balance out the difference that existed up to a few years ago with the more developed countries. The appearance of CVD in young subjects, without any other apparent cause, will force us to rule out a possible HIV infection in high risk individuals
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