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Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
Published on: May 8, 2016
Do chemokines spark autoimmunity in juvenile and adult rheumatic disease?
Harald Mangge1, Jelena Vojinovic, Konrad Schauenstein
1Department of Laboratory Medicine, University of Graz, Austria. harald-mangge@uni-graz.at
Abstract:
The recent increase in knowledge on chemokines contributes substantially to the understanding of autoimmune inflammatory diseases, as cell migration is an essential prerequisite for the local immune reaction. The purpose of this review is to summarize the essential functions of chemokines in immune activation and to examine their role(s) in the initiation and perpetuation of autoimmunity in juvenile idiopathic arthritis and adult rheumatic disease. The possible relevance of chemokines as therapeutical targets will be discussed.
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