The kinetic spectrum of APD
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Updated: Sep 28, 2026

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
Published on: March 11, 2021
1Department of Medicine, University of California - San Francisco, School of Medicine, San Francisco, California, USA. frank.gotch@fmc-na.com
Abstract:
A generalized kinetic model to quantify the efficiency of cycler (CPD) and tidal peritoneal dialysis (TPD) is used to examine the relative efficiency of these techniques over a wide range of tidal volumes, drain profile characteristics, and hourly dialysate flow rates. In the patient with good catheter function, there is little difference in efficiency between CPD and TPD. In patients with long drain times or nonlinear drain profiles, greatly improved efficiency may theoretically be achieved with small tidal volume TPD. A generalized solution of the continuous flow PD (CFPD) kinetic model is used to demonstrate and contrast the kinetics of automated PD (APD) and CFPD.
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