Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Host defenses in APD.

Reinhard R Brunkhorst1

  • 1Division of Nephrology, Hannover Medical School, Hannover, Germany. sekretariat.brunkhorst.oststadt@klinikum-hannover.de

Seminars in Dialysis
|November 20, 2002
PubMed
Summary
This summary is machine-generated.

Automated peritoneal dialysis (APD) reduces peritonitis risk. Longer intervals without dialysis fluid exchanges increase protective peritoneal macrophages, enhancing the body's first-line defense against infection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individualized PD prescription: APD versus CAPD.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysisยท2005
See all related articles

Area of Science:

  • Nephrology
  • Immunology
  • Peritoneal Dialysis

Background:

  • Peritonitis incidence in peritoneal dialysis (PD) has decreased with automated peritoneal dialysis (APD).
  • Technical improvements and enhanced host defense mechanisms in APD have been suggested.
  • The role of dialysate-free intervals in modulating peritoneal immunity requires further clarification.

Purpose of the Study:

  • To investigate the impact of automated peritoneal dialysis (APD) on peritoneal host defense mechanisms.
  • To determine the effect of prolonged daytime intervals without dialysate exchange on peritoneal macrophages and cytokine release.
  • To compare the immunomodulatory effects of different PD modalities.

Main Methods:

  • Analysis of peritoneal cell populations, specifically macrophages, in patients undergoing APD.

Related Experiment Videos

  • In vitro stimulation of peritoneal macrophages with lipopolysaccharides (LPS) to assess cytokine release.
  • Comparison of host defense in APD versus continuous cyclic peritoneal dialysis (CCPD).

    • Main Results:

    • APD, particularly the long daytime interval without dialysate, leads to a higher absolute number of peritoneal macrophages.
    • These macrophages exhibit enhanced first-line host defense capabilities, evidenced by increased cytokine release upon LPS stimulation.
    • The 'dry' daytime period in nightly intermittent PD does not offer significant additional benefits to peritoneal host defense compared to CCPD.

    Conclusions:

    • The increased number and enhanced function of peritoneal macrophages during APD contribute to improved host defense.
    • Intervals without peritoneal dialysis are crucial for the regeneration of peritoneal cell populations and immune function.
    • These findings remain relevant despite the availability of more biocompatible PD solutions.