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The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway

Barbara Stecca1, Ariel Ruiz i Altaba

  • 1Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

Journal of Biology
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PubMed

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...