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Catecholamine metabolism: an update on key biosynthetic enzymes and vesicular monoamine transporters
Torgeir Flatmark1, Bjørg Almas, Michael G Ziegler
1Department of Biochemistry and Molecular Biology, University of Bergen, N-5009 Bergen, Norway. torgeir.flatmark@pki.uib.no
Abstract:
At the meeting, new interesting information was presented on the complex regulation of catecholamine (CA) metabolism in different catecholaminergic neuroendocrine cells. In this review we focus on the rate-limiting enzymes in CA biosynthesis, including (1) structure-function relationships, (2) transcriptional and posttranslational regulation, and (3) disease-associated mutant forms. Moreover, some recent studies on the structure and function of the vesicular monoamine transporters are discussed.
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