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Rim and exocytosis: Rab3a-binding and secretion-enhancing domains are separate and function independently
Lei Sun1, Mary A Bittner, Ronald W Holz
1Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0632, USA.
Annals of the New York Academy of Sciences
|November 20, 2002
Abstract:
Rim1 has been identified in brain by its ability to bind Rab3a-GTP and has been postulated to be a Rab3a effector protein. Like Rabphilin3, another putative Rab3a effector protein, Rim1 modulates secretion and contains a zinc-finger and two C2 domains. We have investigated the structural basis for the ability of Rim1 to bind Rab3a-GTP and to stimulate exocytosis in chromaffin cells.