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Related Experiment Videos

Science's signal transduction knowledge environment: the connections maps database.

Nancy R Gough1

  • 1Science's STKE, AAAS, Washington, DC 20005, USA. ngough@aaas.org

Annals of the New York Academy of Sciences
|November 20, 2002
PubMed
Summary
This summary is machine-generated.

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Science

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Scientific Publishing

Background:

  • Knowledge Environments (KE) integrate electronic tools to organize scientific knowledge.
  • AAAS and Stanford University libraries developed KEs for systematic knowledge access.
  • Signal transduction is a complex, cross-disciplinary field requiring organized information.

Purpose of the Study:

  • Introduce Science's Signal Transduction Knowledge Environment (STKE) as a novel electronic publishing platform.
  • Describe the Connections Map database and CMADES software for signal transduction pathway data management.
  • Highlight the utility of these tools for organizing and accessing expert-curated information.

Main Methods:

  • Development of the Connections Map database for graphical representation of signaling molecules.

Related Experiment Videos

  • Creation of Connections Maps Authority Data Entry Software (CMADES) for automated data input.
  • Utilizing a graphing tool within CMADES to define relationships between pathway components.

    • Main Results:

    • STKE combines traditional publishing with advanced information organization tools.
    • CMADES streamlines the addition of references, descriptors, and pathway relationships.
    • Connections Maps provide a visual, database-driven overview of cellular signaling cascades.

    Conclusions:

    • STKE and its associated tools (Connections Map, CMADES) enhance the organization of signal transduction knowledge.
    • These evolving tools facilitate systematic information management at organism, cell-specific, and canonical levels.
    • STKE offers users organized, expert-supplied information on signal transduction pathways.