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Updated: Sep 28, 2026

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
Published on: September 16, 2018
Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis
Carolann McGuire1, Weng C Chan, Derek Wakelin
1School of Life and Environmental Sciences, University of Nottingham, University Park, United Kingdom.
Abstract:
Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.
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