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Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae
Waldemar Vollmer1, Alexander Tomasz
1Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA.
Infection and Immunity
|November 20, 2002
Abstract:
Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.