Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ross operation with a tissue-engineered heart valve.

Pascal M Dohmen1, Alexander Lembcke, Holger Hotz

  • 1Department of Cardiovascular Surgery, Charité, Humboldt University Berlin, Germany. pascal.dohmen@charite.de

The Annals of Thoracic Surgery
|November 21, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Two-Step Risk Score for Prediction of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation.

Journal of the American Heart Association·2025
Same author

Predictors of residual tricuspid regurgitation after interventional therapy: an automated deep-learning CT analysis.

Scientific reports·2024
Same author

Minimally invasive direct coronary artery bypass and percutaneous coronary intervention followed by transcatheter aortic valve implantation: A promising concept in high-risk octogenarians.

Annals of cardiac anaesthesia·2023
Same author

Sarcomeric network analysis of ex vivo cultivated human atrial appendage tissue using super-resolution microscopy.

Scientific reports·2023
Same author

Acute Lymphocytic Myocarditis in a Young Male Post-COVID-19.

Case reports in cardiology·2023
Same author

Systemic thrombo-embolic events in a middle-aged male with Loeffler endocarditis without peripheral eosinophilia-a case report.

BMC cardiovascular disorders·2022

This study demonstrates a successful tissue-engineered pulmonary allograft for right ventricular outflow tract reconstruction in a Ross procedure. The engineered valve showed excellent function and no calcification after one year.

Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • The Ross procedure uses a patient's own pulmonary valve to replace a diseased aortic valve, requiring right ventricular outflow tract (RVOT) reconstruction.
  • This study explores a tissue-engineered (TE) pulmonary allograft seeded with autologous vascular endothelial cells (AVEC) for RVOT repair.

Observation:

  • A decellularized cryopreserved pulmonary allograft was successfully seeded with cultured AVEC, achieving high cell viability and reendothelialization.
  • A 43-year-old patient with aortic valve stenosis received the TE allograft during a Ross operation.

Findings:

  • Postoperative follow-up using echocardiography, MRI, and CT scans revealed excellent hemodynamic function of the TE pulmonary allograft and the neoaortic valve.
  • No valvular calcification was observed in the TE graft after one year.

Related Experiment Videos

Implications:

  • This approach offers a promising alternative for RVOT reconstruction in the Ross procedure, potentially improving long-term outcomes.
  • The use of autologous cells and decellularized allografts may reduce immunogenicity and enhance graft integration.