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Related Experiment Videos

The latex-fruit syndrome.

S Wagner1, H Breiteneder

  • 1Department of Pathophysiology, University of Vienna, AKH-EBO 3Q, Waehringer Guertel 18-20, Austria. Stefan.Wagner@akh-wien.ac.at

Biochemical Society Transactions
|November 21, 2002
PubMed
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Individuals with natural rubber latex (NRL) allergy often react to plant foods, a condition known as latex-fruit syndrome. This cross-reactivity is linked to similar protein structures recognized by IgE antibodies.

Area of Science:

  • Immunology
  • Allergology
  • Biochemistry

Background:

  • Natural rubber latex (NRL) allergy is frequently associated with hypersensitivity to plant-derived foods, particularly fruits, a phenomenon termed latex-fruit syndrome.
  • This syndrome involves cross-reactivity between NRL allergens and proteins found in foods like avocado, banana, kiwi, and potato.
  • The underlying mechanism is believed to involve IgE antibodies recognizing similar epitopes on related or evolutionarily conserved proteins.

Purpose of the Study:

  • To explore the association between natural rubber latex allergy and hypersensitivity to plant-derived foods.
  • To identify key allergens and protein structures involved in the latex-fruit syndrome.
  • To investigate the role of IgE cross-reactivity in latex-fruit syndrome.

Main Methods:

Related Experiment Videos

  • Analysis of IgE antibody cross-reactivity between NRL allergens and plant food proteins.
  • Identification of specific allergenic proteins, including Class I chitinases, beta-1,3-glucanases, and patatin-like proteins.
  • Investigation of profilin's role in patients with associated pollinosis and latex-fruit syndrome.

Main Results:

  • Class I chitinases in NRL cross-react with hevein (Hev b 6.02), a major NRL allergen.
  • Beta-1,3-glucanase from NRL shows cross-reactivity with bell pepper proteins.
  • Hev b 7, a patatin-like protein in NRL, cross-reacts with potato proteins.
  • Profilin sensitization is common in patients with food allergy, pollinosis, and may lead to positive NRL IgE tests.

Conclusions:

  • The latex-fruit syndrome is mediated by IgE cross-reactivity to structurally similar allergens, particularly plant defense proteins.
  • Specific allergens like chitinases, beta-1,3-glucanases, and patatin-like proteins are implicated in NRL and food allergies.
  • Further research is needed to determine the temporal relationship between latex sensitization and food allergy onset.