Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural biology of C1.

G J Arlaud1, C Gaboriaud, N M Thielens

  • 1Laboratoire d'Enzymologie Moléculaire, Institut de Biologie Structurale Jean-Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France. arlaud@ibs.fr

Biochemical Society Transactions
|November 21, 2002
PubMed
Summary

The classical complement pathway

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting efficacy in patients with locally advanced/metastatic urothelial carcinoma (mUC) treated with immunotherapy using explainable machine learning approaches: the SamUR-AI trial on behalf of the Meet-URO group.

ESMO real world data and digital oncology·2026
Same author

Polyethylene microplastics alter root functionality and affect strawberry plant physiology and fruit quality traits.

Journal of hazardous materials·2024
Same author

Early prediction of endocrine responsiveness in ER+/HER2-negative metastatic breast cancer (MBC): pilot study with <sup>18</sup>F-fluoroestradiol (<sup>18</sup>F-FES) CT/PET.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents with Down syndrome.

Journal of endocrinological investigation·2023
Same author

The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse model.

Human reproduction (Oxford, England)·2021
Same author

Managing chronic disease in the COVID-19 pandemic: an e-learning application to promote a healthy lifestyle for persons with multiple sclerosis.

Psychology, health & medicine·2021

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • The classical complement pathway is crucial for innate immunity and involved in immune tolerance, graft rejection, and diseases.
  • This pathway is initiated by the C1 complex, a protease composed of C1q and a C1r-C1s tetramer.

Purpose of the Study:

  • To elucidate the structure-function relationships of the C1 complex.
  • To understand the mechanisms of C1 activation and proteolytic activity.

Main Methods:

  • Dissection of C1 proteins into modular segments.
  • X-ray crystallography and NMR spectroscopy to determine three-dimensional structures.
  • Biochemical and electron microscopy studies.

Main Results:

  • Characterization of the domain structure of C1 subcomponents.
  • A low-resolution model of the C1 complex was developed.
  • Detailed insights into C1 assembly, activation, and proteolytic functions were gained.

Conclusions:

  • Understanding C1 structure is key to its function in the complement system.
  • This research provides a foundation for further studies on complement-mediated processes and pathologies.

Related Experiment Videos