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Ribozyme-catalysed carbon-carbon bond formation
A Jäschke1, F Stuhlmann, D Bebenroth
1Department of Biology, Chemistry & Pharmacy, Institute of Chemistry, Freie Universität Berlin, Thielallee 63, Germany. jaeschke@uni-hd.de
Biochemical Society Transactions
|November 21, 2002
Abstract:
Numerous RNA molecules with new catalytic properties have been isolated from synthetic combinatorial libraries. A broad range of chemical reactions is catalysed, and nucleic acids can accelerate bond formation between small organic substrates. This review focuses on carbon-carbon bond formation accelerated by in vitro selected ribozymes. Mechanistic investigations and structure-function relationships are discussed.