Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial function in sustained and white coat hypertension.

Sante D Pierdomenico1, Francesco Cipollone, Domenico Lapenna

  • 1Centro per lo Studio dell'Ipertensione Arteriosa, delle Dislipidemie e dell'Arteriosclerosi, Dipartimento di Medicina e Scienze dell'Invecchiamento, University Gabriele d'Annunzio, Via dei Vestini, 66013 Chieti Scalo (Chieti), Italy. pierdomenico@unich.it

American Journal of Hypertension
|November 21, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-World Effectiveness of Baricitinib in Rheumatoid Arthritis: Significant Reduction of Disease Activity Independent of Age in a Multicentre Retrospective Cohort Study.

Mediterranean journal of rheumatology·2026
Same author

Six months predictors of DAPSA Remission With Guselkumab in Psoriatic Arthritis in a Multicenter Real-World Study.

Scientific reports·2026
Same author

OUtcome and Clinical Characteristics of Primary Headache in Patients with Sarcoidosis: The OUCH! Study.

Life (Basel, Switzerland)·2026
Same author

Effects of glucagon-like peptide-1 receptor agonists and dual glucagon-like peptide-1 receptor agonists/glucose-dependent insulinotropic polypeptide on liver stiffness and steatosis evaluated through Fibroscan<sup>®</sup>: a systematic review and meta-analysis.

Internal and emergency medicine·2026
Same author

Drug retention of TNF versus IL-23 inhibitors in psoriatic arthritis: a multicenter real-life cohort study.

Therapeutic advances in musculoskeletal disease·2026
Same author

Significance of 8-iso-PGF<sub>2α</sub> in cardiovascular diseases.

American heart journal plus : cardiology research and practice·2026

Middle-aged individuals with white coat hypertension exhibit normal endothelial function, unlike those with sustained hypertension. This suggests white coat hypertension may not indicate underlying endothelial dysfunction when other cardiovascular risks are absent.

Area of Science:

  • Cardiovascular Physiology
  • Hypertension Research
  • Endothelial Function Studies

Background:

  • Endothelial dysfunction is common in essential hypertension.
  • White coat hypertension (WCH) requires further investigation regarding endothelial health.
  • Assessing endothelial function in WCH is crucial for understanding cardiovascular risk.

Purpose of the Study:

  • To compare endothelial function in white coat hypertension (WCH) versus sustained hypertension (SH) and normotensive (NT) individuals.
  • To evaluate circulating nitric oxide metabolites (NOx) and endothelium-dependent vasodilation (EDD) as markers of endothelial function.
  • To determine if WCH is associated with endothelial dysfunction.

Main Methods:

  • Cross-sectional study comparing 22 WCH, 22 SH, and 22 NT subjects matched for demographics.

Related Experiment Videos

  • Exclusion of subjects with smoking, dyslipidemia, or diabetes.
  • Measurement of NOx levels and brachial artery ultrasonography for EDD and endothelium-independent vasodilation after a low-nitrate diet.

    • Main Results:

    • WCH subjects showed significantly higher NOx levels and EDD compared to SH patients (P < .05).
    • No significant differences in NOx or EDD were found between WCH and NT subjects.
    • Endothelium-independent vasodilation did not differ significantly among the three groups.

    Conclusions:

    • Middle-aged WCH subjects without additional cardiovascular risk factors do not exhibit endothelial dysfunction.
    • Sustained hypertensive patients demonstrate impaired endothelial function compared to WCH.
    • Findings suggest WCH may represent a distinct clinical entity from SH regarding endothelial health.