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Published on: October 12, 2017

[Effect of antianginal therapy on lipid peroxidation in patients with ischemic heart disease]

V G Selivonenko, S S Boev, E S Torbin

    Likars'Ka Sprava
    |November 22, 2002
    PubMed

    Insights

    Antianginal therapy minimally impacts blood lipid peroxidation products like dienic ketones and malonic dialdehyde in patients with angina and postinfarction cardiosclerosis. This suggests a need for antioxidant agents to manage oxidative stress in these conditions.

    Area of Science:

    • Cardiology
    • Biochemistry
    • Pharmacology

    Context:

    • Investigates oxidative stress markers in cardiovascular diseases.
    • Focuses on stable angina of effort and postinfarction cardiosclerosis.
    • Considers the impact of ejection fraction on lipid peroxidation.

    Purpose:

    • To measure blood lipid peroxidation products in patients with stable angina and postinfarction cardiosclerosis.
    • To evaluate the effect of antianginal therapy on these oxidative stress markers.
    • To determine the potential need for antioxidant agents.

    Summary:

    • Blood levels of lipid hydroperoxides, dienic ketones, and malonic dialdehyde were measured in 26 patients with stable angina and 31 with postinfarction cardiosclerosis.
    • Measurements were taken before and after antianginal therapy (nitrates, beta-blockers, nifedipine), considering ejection fraction.
    • Antianginal therapy showed minimal effect on dienic ketones and malonic dialdehyde, indicating limited impact on lipid peroxidation.

    Impact:

    • Highlights the limited efficacy of standard antianginal drugs in reducing key lipid peroxidation markers.
    • Suggests that antioxidant agents may be beneficial for managing oxidative stress in these patient groups.
    • Provides evidence for a potential adjunctive therapeutic strategy in cardiovascular disease management.

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