Related Experiment Video
Updated: Aug 14, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
Published on: December 14, 2014
The effects of oral carbohydrate administration on fetal acid base balance
Hubertina C J Scheepers1, Marion C J Thans, Pieter A de Jong
1Department of Gynecology and Obstetrics, Leiden University Medical Center, Leiden, The Netherlands. HCJ.Scheepers@kabelfoon.nl
Aims:
Little evidence-based data are available on the effects of eating and drinking during labor. Intravenous glucose administration has been related to fetal metabolic acidosis. The question is, whether oral intake of carbohydrates effects the fetal acid-base balance.
Methods:
In a double blind, prospective placebo controlled study 100 nulliparous women were randomized at 8-10 cm of cervical dilatation. All women were asked to drink 200 cc of either a carbohydrate solution (containing 25 grams carbohydrates) or placebo. In all women, both arterial and venous umbilical cord pH, pCO2, pO2, HCO3- and base excess/deficit were assessed. In a subgroup of women, whose deliveries were complicated by mild signs of fetal distress, clinical outcome and acid-base status was described separately.
Results:
Fetal arterial umbilical cord pH were identical: 7.20 +/- 0.07 in the placebo group and 7.20 +/- 0.08 in the carbohydrate group and the base excess -6.6 +/- 2.8 versus 6.6 +/- 3.7. In the women with mild signs of fetal distress, no differences were observed as well.
Conclusions:
Oral carbohydrate intake during labor seems to be safe regarding the fetal acid-base balance. Further study on the maternal and fetal metabolic parameters is essential to give a more complete picture.
Related Concept Videos
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Acid-Base Balance
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
Respiratory Regulation of Acid-Base Balance
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are produced, leading to a...
Disorders of Acid-Base Balance
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Diagnosing Acidosis and Alkalosis
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and HCO3− values are examined to...
Development of the Oral Microbiota

