Methods of developmental research

Neural tube defects (NTD) caused by abnormal neurulation are the major congenital anomalies which result in fetal or embryonic death, and medical, financial and social problems. The multifactorial events of neurulation have attracted researchers to identify the mechanisms of this disability. Research focused on NTDs is one of the major topics in developmental experiments. Mammalian, avian, amphibian and computer models are used as fundamental models to discover specific events causing NTDs. There are advantages of working on some models: rats and mice are mammalian models of neurulation; amphibians and avian embryos are simple models and more practical. Advancement in laboratory techniques has yielded more detailed information about neurulation which will assist in future with prevention and therapy of these defects.