Related Experiment Video
Updated: Aug 13, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
Published on: April 24, 2016
[Use of saliva substitutes in patients with xerostomia]
Hendrik Meyer-Lueckel1, Andrej M Kielbassa
1Poliklinik für Zahnerhaltungskunde und Parodontologie, Universitätsklinik für Zahn-, Mund- und Kieferheilkunde, Freie Universität Berlin. meylue@zedat.fu-berlin.de
Abstract:
For alleviation of the distressing symptoms of xerostomia various saliva substitutes are commercially available. The dental literature provides scanty information concerning the subjective relief of oral dryness obtained from the use of these products. Additionally, the rheological properties of the containing polymers, e.g. the viscosity and the lubrication, seem to influence the clinical acceptance of the artificial salivas. Moreover, a demineralizing effect on the dental hard tissues could be observed for some of these products in vitro. A saliva substitute having a remineralizing effect on dentin and enamel, showing preferable rheological properties as well as a long lasting relieve of oral symptoms of mouth dryness seems to be preferable.
Related Concept Videos
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Cholinergic Antagonists: Pharmacokinetics
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Drug Delivery: Enteral Route
Drugs in...
Oral Drug Delivery Systems: Introduction
Oral Drug Delivery Systems: Continuous-Release Systems

