Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Geometry of lipid vesicle adhesion.

R Capovilla1, J Guven

  • 1Departamento de Física, Centro de Investigación y de Estudios Avanzados del IPN, Apartado Postal 14-740, 07000 México, DF, Mexico. capo@fis.cinvestav.mx

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|November 22, 2002
PubMed
Summary

This study explores lipid membrane vesicle adhesion to substrates using geometry. It reveals how vesicle shape and substrate interactions dictate adhesion forces and boundary conditions without assuming symmetry.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid membranes with an edge.

Physical review. E, Statistical, nonlinear, and soft matter physics·2002
See all related articles

Area of Science:

  • Biophysics
  • Soft Matter Physics
  • Surface Science

Background:

  • Lipid membrane vesicles are fundamental biological structures.
  • Understanding vesicle adhesion is crucial for cell mechanics and drug delivery.
  • Existing models often simplify vesicle and substrate geometries.

Purpose of the Study:

  • To geometrically analyze lipid membrane vesicle adhesion to a substrate.
  • To investigate the role of Helfrich Hamiltonian and contact interactions.
  • To determine boundary constraints and force balances during adhesion.

Main Methods:

  • Geometric analysis of vesicle-substrate contact.
  • Application of the Helfrich Hamiltonian (quadratic in mean curvature).
  • Modeling interaction energy proportional to contact area.

Related Experiment Videos

Main Results:

  • Identified geometrical constraints at the boundary of the contact area.
  • Interpreted results in terms of normal force balance at the boundary.
  • Demonstrated applicability without assuming vesicle or substrate symmetry.

Conclusions:

  • The study provides a general geometric framework for vesicle adhesion.
  • It highlights the importance of boundary geometry and force balance.
  • The model accounts for strong bonding and curvature asymmetry effects.