Related Experiment Videos
Tylosin depletion from edible pig tissues
C Prats1, G El Korchi, R Francesch
1Departament de Farmacologia i Terapèutica, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain. carme.prats@uab.es
Research in Veterinary Science
|November 22, 2002
Summary
Tylosin residue in pig tissues like kidney and skin exceeded the EU limit for 7 days post-treatment. However, tylosin levels fell below detectable limits by 10-14 days, ensuring food safety.
Area of Science:
- Veterinary Pharmacology
- Food Safety
- Analytical Chemistry
Background:
- Tylosin is an antibiotic commonly used in swine production.
- Understanding tylosin depletion is crucial for ensuring food safety and compliance with regulatory limits.
- Intramuscular administration is a common route for tylosin delivery in pigs.
Purpose of the Study:
- To determine the depletion rate of tylosin in various edible pig tissues.
- To assess tylosin residue concentrations against the European Union's maximal residue limit (MRL).
Main Methods:
- Sixteen crossbreed pigs were administered tylosin intramuscularly at 10 mg/kg for 5 days.
- Tissue samples (muscle, kidney, liver, skin+fat, injection site) were collected at set intervals post-treatment.
- High-performance liquid chromatography (HPLC) was used to quantify tylosin concentrations.
Main Results:
- Tylosin concentrations in kidney, skin+fat, and injection site tissues exceeded the EU MRL of 100 microg/kg at 7 days post-treatment.
- Residue levels in all studied tissues fell below the quantification limit (50 microg/kg) by 10 and 14 days post-treatment.
Conclusions:
- Tylosin withdrawal periods need careful consideration to ensure edible tissues are below the MRL.
- A 7-day post-treatment period is insufficient to guarantee tylosin residue depletion below the EU MRL in certain pig tissues.
- Further studies may be warranted to establish optimal withdrawal times for tylosin in swine.