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Synthesis and cytotoxic activity of a new potent daunomycinone derivative
Nectarios Aligiannis1, Nicole Pouli, Panagiotis Marakos
1Division of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Greece.
Bioorganic & Medicinal Chemistry Letters
|November 22, 2002
Abstract:
The preparation and cytotoxic activity of 4'-azido-3'-bromo-3'-deamino-4'-deoxydaunorubicin is described. The new compound was found to be less active in vitro than adriamycin against L1210 and the sensitive cell lines KB-3-1 and MES-SA, but retained interesting cytotoxicity against the adriamycin resistant subline KB-A1 and the multidrug resistant MES-SA/Dx5 subline.