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Synthesis and biological evaluation of aristolactams
Axel Couture1, Eric Deniau, Pierre Grandclaudon
1Laboratoire de Chimie Organique Physique, ESA CNRS 8009, Bâtiment C3(2), UST Lille, F-59655 Villeneuve d'Ascq Cédex, France. axel.couture@univ-lille1.fr
Bioorganic & Medicinal Chemistry Letters
|November 22, 2002
Abstract:
A variety of aristolactam derivatives were synthesized and evaluated for cytotoxicity. Modulations were carried out on the phenanthrene nucleus and the lactam moiety as well. N-(N-dialkylaminoalkyl) derivatives exhibited interesting cytotoxic activity against the L1210 leukemia cell line.